Daniel S. Evans, PhD, MPH

Scientist, California Pacific Medical Center Research Institute

Phone: 415-476-6090
E-Mail: [email protected]
Address:

Box 0560
550 16th Street, 2nd Floor
San Francisco, CA 94158

Additional Websites:

California Pacific Medical Center, Research Institute

Dr. Evans received a PhD from the Molecular and Cell Biology Department at UC Berkeley where he used molecular genetic approaches to study oogenesis and the neural basis of stereotyped behaviors in the model organism Drosophila melanogaster. Following that, Dr. Evans received an MPH from the School of Public Health at UC Berkeley specializing in epidemiology. Dr. Evans is a genetic epidemiologist with expertise in the analysis of large-scale genomic data on high-performance compute clusters. 

Longevity Genomics Research Project. In this project, we are using longevity-associated variants, gene expression studies, and evidence from model organisms to identify longevity-associated genes (LAGs). New expression signatures associated with human aging are being pursued. Mendelian randomization analysis is used to evaluate the potential impact modulating LAG activity might have on longevity and other age-related diseases in an Aging PheWAS. More can be found here: http://www.longevitygenomics.org/.

Research Interests

  • Human genetics 
  • Aging
  • Longevity
  • Osteoporosis

Selected Publications

Visit PubMed to see additional publications

  1. Deelen J, Evans DS, Arking DE, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 Aug 14;10(1):3669. PMID: 31413261.
  2. Baird DA, Evans DS, Kamanu FK, et al. J Bone Miner Res. 2019 Feb;34(2):241-251. PMID: 30320955.
  3. Zillikens MC, Demissie S, Hsu YH, et al., Evans DS. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 Jul 19;8(1):80. Erratum in: Nat Commun. 2017 Nov 7;8(1):1414. PMID: 28724990.
  4. Evans DS, Avery CL, Nalls MA, et al. Hum Mol Genet. 2016 Oct 1;25(19):4350-4368. PMID: 27577874.
  5. Willcox BJ, Tranah GJ, Chen R, et al., Evans DS. The FoxO3 gene and cause-specific mortality. Aging Cell. 2016 Aug;15(4):617-24. PMID: 27071935.
  6. Cade BE, Gottlieb DJ, Lauderdale DS, et al., Evans DS. Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet. 2016 Jan 1;25(1):167-79. PMID: 26464489.
  7. Gottlieb DJ, Hek K, Chen TH, et al., Evans DS. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry. 2015 Oct;20(10):1232-9. PMID: 25469926.
  8. Zheng HF, Forgetta V, Hsu YH, et al., Evans DS. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature. 2015 Oct 1;526(7571):112-7. PMID: 26367794.
  9. Evans DS, Cailotto F, Parimi N, et al. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis. 2015 Oct;74(10):1861-7. PMID: 24928840.
  10. Eriksson J, Evans DS, Nielson CM, et al. Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. J Bone Miner Res. 2015 Jan;30(1):184-94. PMID: 25043339.
  11. Patel SR, Hayes AL, Blackwell T, Evans DS, et al. The association between sleep patterns and obesity in older adults. Int J Obes (Lond). 2014 Sep;38(9):1159-64. PMID: 24458262.
  12. Arking DE, Pulit SL, Crotti L, et al., Evans DS. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014 Aug;46(8):826-36. PMID: 24952745.
  13. Ng MC, Shriner D, Chen BH, et al., Evans DS. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug 7;10(8):e1004517. PMID: 25102180.
  14. Evans DS, Calton MA, Kim MJ, et al. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014 May 12;9(5):e96805. PMID: 24820477.
  15. Evans DS, Parimi N, Nievergelt CM, et al. Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. Sleep. 2013 Mar 1;36(3):431-46. PMID: 23449886.
  16. Butler AM, Yin X, Evans DS, et al. Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. Circ Cardiovasc Genet. 2012 Dec;5(6):639-46. PMID: 23139255. 
  17. Swarbrick MM, Evans DS, Valle MI, et al. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring). 2011 Dec;19(12):2394-2403. PMID: 21512513.
  18. Evans DS, Snitker S, Wu SH, et al. Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factors. Sleep. 2011 May 1;34(5):661-9. PMID: 21532960.
  19. Evans DS, Kapahi P, Hsueh WC, Kockel L. TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev. 2011 Apr;10(2):225-37. PMID: 20385253.
  20. Smith JG, Magnani JW, Palmer C, et al., Evans DS. Genome-wide association studies of the PR interval in African Americans. PLoS Genet. 2011 Feb 10;7(2):e1001304. PMID: 21347284.