Scientist, California Pacific Medical Center Research Institute
 

Box 0560
550 16th Street, 2nd Floor
San Francisco, CA 94158

Additional Websites:

California Pacific Medical Center, Research Institute

Daniel S Evans, PhD is Senior Scientist at the California Pacific Medical Center Research Institute (CPMCRI) and the San Francisco Coordinating Center (SFCC), as well as an Adjunct Associate Professor in the Department of Epidemiology and Biostatistics at the University of California, San Francisco. Dr. Evans received his PhD and MPH from UC Berkeley. His research involves the analysis of high-dimensional genomic data in large clinical research studies to identify and characterize factors associated with human aging. In this work, Dr. Evans combines his expertise in genomics, aging, and epidemiology to perform statistical analysis that is appropriate for the data and study design characteristics of a research initiative. He works in large collaborative consortia to perform Genome-wide Association Study (GWAS) meta-analyses of human lifespan, osteoporosis, osteoarthritis, and body composition, among other aging-related traits. As a PI of the multiple-PI Longevity Genomics research program, he integrated genome-wide genetic data with gene expression to identify translational strategies related to the human lifespan. In collaborative translational studies with laboratory scientists at UCSF, he integrated mouse bone transcriptomics and GWAS to discover genes that change expression with age in mouse bone and that are associated with bone mineral density and fracture. In the Longevity Consortium (LC), Dr. Evans and colleagues designed a case-cohort study that combined biospecimens and data across four longitudinal cohort studies of elderly individuals to identify predictive metabolomic and proteomic biomarkers associated with future achievement of longevity (reaching the top 98th percentile of survival for sex and birth cohort).

Research Interests

• Human genetics 
• Aging/Longevity
• Metabolomics
• Musculoskeletal conditions

Selected Publications

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1. Evans DS, Young D, Tanaka T, Basisty N, Bandinelli S, Ferrucci L, Campisi J, Schilling B. Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits. J Gerontol A Biol Sci Med Sci. 2024 Mar 1;79(3):glad265. doi: 10.1093/gerona/glad265. PMID: 37982669; PMCID: PMC10876076. 

2. Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., Schroeder, P., Vanderwerff, B., … Zeggini, E. (2024). Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), 347–357.  

3. Kaya S, Alliston T, Evans DS. Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research. Curr Osteoporos Rep. 2023 Dec;21(6):637-649. doi: 10.1007/s11914-023-00821-7. Epub 2023 Oct 13. PMID: 37831357. 

4. Faber BG, Frysz M, Boer CG, Evans DS, Ebsim R, Flynn KA, Lundberg M, Southam L, Hartley A, Saunders FR, Lindner C, Gregory JS, Aspden RM, Lane NE, Harvey NC, Evans DM, Zeggini E, Davey Smith G, Cootes T, Van Meurs J, Kemp JP, Tobias JH. The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. EBioMedicine. 2023 Sep;95:104759. doi: 10.1016/j.ebiom.2023.104759. Epub 2023 Aug 22. PMID: 37619450; PMCID: PMC10470292. 

5. Kaya S, Bailey KN, Schurman CA, Evans DS, Alliston T. Bone-cartilage crosstalk informed by aging mouse bone transcriptomics and human osteoarthritis genome-wide association studies. Bone Rep. 2022 Dec 13;18:101647. doi: 10.1016/j.bonr.2022.101647. PMID: 36636109; PMCID: PMC9830153. 

6. Evans DS. Target Discovery for Drug Development Using Mendelian Randomization. Methods Mol Biol. 2022;2547:1-20. doi: 10.1007/978-1-0716-2573-6_1. PMID: 36068458. 

7. Young WJ, Lahrouchi N, Isaacs A, et al. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nat Commun. 2022;13(1):5144. Published 2022 Sep 1. doi:10.1038/s41467-022-32821-z 

8. Kim KM, Evans DS, Jacobson J, Jiang X, Browner W, Cummings SR. Rapid prediction of in-hospital mortality among adults with COVID-19 disease. PLoS One. 2022 Jul 29;17(7):e0269813. doi: 10.1371/journal.pone.0269813. PMID: 35905072; PMCID: PMC9337639. 

9. Kaya S, Schurman CA, Dole NS, Evans DS, Alliston T. Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses. J Bone Miner Res. 2022 Apr;37(4):804-817. doi: 10.1002/jbmr.4516. Epub 2022 Feb 28. PMID: 35094432; PMCID: PMC9018503. 

10. Evans DS, O'Leary MN, Murphy R, Schmidt M, Koenig K, Presley M, Garrett B, Kim HN, Han L, Academia EC, Laye MJ, Edgar D, Zambataro CA, Barhydt T, Dewey CM, Mayfield J, Wilson J, Alavez S, Lucanic M, Kennedy BK, Almeida M, Andersen JK, Kapahi P, Lithgow GJ, Melov S. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021 Feb 16;5(3):e10466. doi: 10.1002/jbm4.10466. PMID: 33778327; PMCID: PMC7990142. 

11. Deelen J, Evans DS, Arking DE, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes [published correction appears in Nat Commun. 2021 Apr 23;12(1):2463]. Nat Commun. 2019;10(1):3669. Published 2019 Aug 14. doi:10.1038/s41467-019-11558-2 

12. Wolters FJ, Yang Q, Biggs ML, Jakobsdottir J, Li S, Evans DS, Bis JC, Harris TB, Vasan RS, Zilhao NR, Ghanbari M, Ikram MA, Launer L, Psaty BM, Tranah GJ, Kulminski AM, Gudnason V, Seshadri S; E2-CHARGE investigators. The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE). PLoS One. 2019 Jul 29;14(7):e0219668. doi: 10.1371/journal.pone.0219668. PMID: 31356640; PMCID: PMC6663005. 

13. Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F; GEFOS/GENOMOS consortium and the 23andMe research team. Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. BMJ. 2018 Aug 29;362:k3225. doi: 10.1136/bmj.k3225. PMID: 30158200; PMCID: PMC6113773. 

14. Evans DS, Avery CL, Nalls MA, et al. Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet. 2016;25(19):4350-4368. doi:10.1093/hmg/ddw284 

15. Zheng HF, Forgetta V, Hsu YH, et al. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature. 2015;526(7571):112-117. doi:10.1038/nature14878 

16. Evans DS, Cailotto F, Parimi N, Valdes AM, Castaño-Betancourt MC, Liu Y, Kaplan RC, Bidlingmaier M, Vasan RS, Teumer A, Tranah GJ, Nevitt MC, Cummings SR, Orwoll ES, Barrett-Connor E, Renner JB, Jordan JM, Doherty M, Doherty SA, Uitterlinden AG, van Meurs JB, Spector TD, Lories RJ, Lane NE. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis. 2015 Oct;74(10):1861-7. doi: 10.1136/annrheumdis-2013-205020. Epub 2014 Jun 13. PMID: 24928840; PMCID: PMC4449305. 

17. Evans DS, Parimi N, Nievergelt CM, Blackwell T, Redline S, Ancoli-Israel S, Orwoll ES, Cummings SR, Stone KL, Tranah GJ; Study of Osteoporotic Fractures (SOF); Osteoporotic Fractures in Men (MrOS) Study Group. Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. Sleep. 2013 Mar 1;36(3):431-46. doi: 10.5665/sleep.2466. PMID: 23449886; PMCID: PMC3571755. 

18. Evans DS, Snitker S, Wu SH, Mody A, Njajou OT, Perlis ML, Gehrman PR, Shuldiner AR, Hsueh WC. Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factors. Sleep. 2011 May 1;34(5):661-9. doi: 10.1093/sleep/34.5.661. PMID: 21532960; PMCID: PMC3079946. 

19. Evans DS, Kapahi P, Hsueh WC, Kockel L. TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev. 2011 Apr;10(2):225-37. doi: 10.1016/j.arr.2010.04.001. Epub 2010 Apr 10. PMID: 20385253; PMCID: PMC2943975.