Gregory J. Tranah, PhD

Scientist, California Pacific Medical Center Research Institute
Phone: 415-476-6135
Fax: 415-514-8150
Address: Box 0560
550 16th Street, 2nd Floor
San Francisco, CA 94159

Additional Websites:

The Longevity Consortium
California Pacific Medical Center, Research Institute

Dr. Tranah has extensive experience and training in molecular epidemiology of aging and age-related diseases. His current work involves the genetics of aging and age-related traits and he is engaged in research to discover the genes associated with longevity. Dr. Tranah is collaborating with investigators from the Study of Osteoporotic Fractures (SOF), the Study of Osteoporosis in Men (MrOS) and the Health, Aging and Body Composition Study to study the genetics of cognitive function, osteoporosis, osteoarthritis, sleep, circadian rhythms and the role of mitochondrial DNA in aging. Dr. Tranah is actively conducting genome wide association studies (GWAS) in the Health, Aging and Body Composition Study and is involved in several collaborations through the CHARGE GWAS consortium by actively participating in the following Working Groups: Musculoskeletal, Aging & Longevity, and Reproductive Aging/BMD. He is the PI of a candidate gene study examining the relationship between circadian and melatonin pathway genes and outcomes related to sleep, circadian rhythms, cognitive function, metabolism, and mortality. This work is being performed in two large population-based studies (SOF and MrOS). Dr. Tranah is also the PI of DNA resequencing studies examining the role of mitochondrial DNA mutations in both pancreatic cancer and human energetics. He is leading a deep sequencing study to identify rare sirtuin gene variants that are associated with surviving to >100 years and is pursuing studies of gene-environment interactions using both GWAS and sequence level data.

Dr. Tranah Discusses His Research on Genetic Variation in Human Aging

Research Interests

  • Human genetics
  • Mechanisms of aging
  • Sleep and circadian rhythms
  • Mitochondrial DNA: energetics, disease and aging
  • Cancer epidemiology and genetics

Selected Publications

Visit PubMed to see additional publications
  1. Yokoyama, J. S., D. Evans, D., G. Coppola, et al., (includes G. J. Tranah). 2014. Genetic modifiers of cognitive maintenance among older adults. Human Brain Mapping. PMID in process.
  2. Moayyeri, A., Y. H. Hsu, D. Karasik, et al., (includes G. J. Tranah). 2014. Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human Molecular Genetics. PMID: 24430505.
  3. Tranah, G. J., J. S.Yokoyama, S. M. Katzman, et al. 2013. Mitochondrial DNA sequence associations with dementia and amyloid-ß in elderly African-Americans. Neurobiology of Aging. PMID: 24140124.
  4. Elbers, C. C., M. E. Garcia, M. Kimura et al., (includes G. J. Tranah). 2013. Comparison between Southern Blots and qPCR analysis of Leukocyte Telomere Length in the Health ABC Study. Journal of Gerontology: Biological Sciences. PMID: 23946336.
  5. D. F. Kripke, C. M. Nievergelt, G. J. Tranah, et al. 2013. FMR1, circadian genes and depression: Suggestive associations or false discovery? J Circadian Rhythms. 11(1):3. PMID: 23521777.
  6. J. E. Maglione, S. Ancoli-Israel, K. W. Peters, et al. (includes G. J. Tranah). 2013. Depressive Symptoms and Circadian Activity Rhythm Disturbances in Community-Dwelling Older Women. American Journal of Geriatric Psychiatry. PMID: 23567424.
  7. D. E. Evans, N. Parimi, C. M. Nievergelt, et al., G. J. Tranah. 2013. Common genetic variants at the ARNTL and NPAS2 loci and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. Sleep. 36(3):431-46. PMID: 23449886.
  8. R. A. Murphy, M. A. Nalls, M. Keller, et al. (includes G. J. Tranah). 2012. Candidate Gene Association Study of BMI-Related Loci, Weight, and Adiposity in Old Age. Journal of the American Geriatrics Society. PMID: 23160366.
  9. Tranah, G. J., M. A. Nalls, S. M. Katzman, et al. 2012. Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly. Journal of Alzheimer's Disease. 32(2). PMID: 22785396.
  10. Tranah, G. J., E. T. Lam, S. M. Katzman, et al. 2012. Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. Biochimica et Biophysica Acta – Bioenergetics. 1817(9):1691-1700. PMID: 22659402.
  11. E. T. Lam, P.M. Bracci, E.A. Holly, et al., G. J. Tranah. 2012. Mitochondrial DNA sequence variation and risk of pancreatic cancer. Cancer Research. 72(3):686-95. PMID: 22174369.
  12. S. Walter, J. Mackenbach, Z. Vokó, et al. (includes G. J. Tranah). 2012. Genetic, Physiological, and Lifestyle Predictors of Mortality in the General Population. Am J Public Health. PMID: 22397355
  13. L. Broer, E. W. Demerath, M. E. Garcia, (includes G. J. Tranah). 2012. Association of heat shock proteins with all-cause mortality. Age. PMID: 22555621.
  14. M. Cesari, S. B. Kritchevsky, B. Nicklas et al. (includes G. J. Tranah). 2012. Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results from the Health Aging and Body Composition Study. Journal of the American Geriatrics Society. PMID: 22389462.
  15. S. P. David, A. Hamidovic, G. K. Chen, et al. (includes G. J. Tranah). 2012. Genome-wide meta-analyses of smoking behaviors in African Americans. Translational Psychiatry. PMID: 22832964.
  16. N. Parimi, T. Blackwell, K. L. Stone, et al. (includes G. J. Tranah). 2012. Hip pain while using lower extremity joints is associated with sleep disturbances in elderly Caucasian women: The study of osteoporotic fractures. Arthritis Care Res. PMID: 22298286.
  17. K. K. Vesco, L. M. Marshall, H. D. Nelson, et al. (includes G. J. Tranah). 2012. Surgical menopause and nonvertebral fracture risk among older US women. Menopause. 19(5):510-6. PMID: 22547252.
  18. Tranah, G. J., T. M. Manini, K. K. Lohman, et al. 2011. Mitochondrial DNA variation in human metabolic rate and energy expenditure. Mitochondrion. 11(6):855-61. PMID: 21586348.
  19. Tranah, G. J., T. Blackwell, K. L. Stone, et al. 2011. Circadian activity rhythms and risk of incident dementia and MCI in older women. Annals of Neurology. 70(5):725-732. PMID: 22162057.
  20. Tranah, G.J. 2011. Mitochondrial-Nuclear Epistasis: Implications for Human Aging and Longevity. Aging Research Reviews. 10(2):238-52. PMID: 20601194.
  21. Kripke, D. F., C. M. Nievergelt, G. J. Tranah, et al. 2011. Polymorphisms in melatonin synthesis pathways: possible influences on depression. Journal of Circadian Rhythms. 9(8). PMID: 21827647.
  22. Walter, S., G. Atzmon, E. W. Demerath, et al. (includes G.J. Tranah). 2011. A genome-wide association study of aging. Neurobiol Aging. 32(11):2109.e15-28. PMID:21782286
  23. Paudel, M. L., B. C. Taylor, S. Ancoli-Israel, et al. (includes G.J. Tranah). 2011. Rest/Activity Rhythms and Cardiovascular Disease in Older Men. Chronobiol Int. 28(3):258-266. PMID: 21452921.
  24. Tranah, G.J., E.A. Holly, F. Wang, P.M. Bracci. 2011. Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area. BMC Cancer. 11:138. PMID: 21496267.
  25. Tranah, G. J., N. Parimi, T. Blackwell, et al. 2010. Postmenopausal hormones and sleep quality in the elderly: a population based study. BMC Women's Health.10:15. PMID: 20441593.