Steven R. Cummings, MD

Director, San Francisco Coordinating Center
Research Scientist, California Pacific Medical Center Research Institute
Professor of Medicine, Epidemiology and Biostatistics, Emeritus
University of California, San Francisco
Phone: 415-476-6088
Fax: 415-514-8150
E-Mail: scummings@sfcc-cpmc.net
Address: Box 0560
550 16th Street, 2nd Floor
San Francisco, CA 94159

Administrative Coordinator: Christina Kouma, CKouma@sfcc-cpmc.net, 415-476-6107
Additional Websites:

Centers for Research in Clinical Excellence, The Longevity Consortium, California Pacific Medical Center, Research Institute

Dr. Cummings is an internationally recognized expert on the epidemiology of osteoporosis, women's health, and aging. He has over 20 years of experience in the design and execution of multicenter observational studies and clinical trials.

Research Interests

  • Biology of aging
  • Efficient design and execution of clinical trials
  • Pathophysiology, epidemiology, and prevention of fractures
  • Postmenopausal women's health
  • Clinical research methods

Selected Publications

Visit PubMed to see additional publications

Aging

  1. Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner A, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E; for the Study of Osteoporotic Fractures. Association of common genetic variation in the insulin/IGF1-signaling pathway with human longevity. Aging Cell 2009; Aug;8:460-72. PMC3652804.
  2. Swindell WR, Ensrud KE, Cawthon PM, Cauley JA, Cummings SR, Miller RA. Indicators of “Healthy Aging” in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival. BMC Geriatr. 2010 Aug 17;10:55. PMC2936300.
  3. Swindell WR, Cummings SR, Sanders JL, Caserotti P, Rosano C, Satterfield S, Strotmeyer ES, Harris TB, Simonsick EM, Cawthon PM. Data mining identifies digit symbol substitution test score and serum cystatin C as dominant predictors of mortality in older men and women. Rejuvenation Res. 2012 Aug;15(4):405-13. PMC3419847.

Methodologies

  1. Hulley SB, Cummings SR, Browner WS, Grady DG, Newman TB (eds). Designing Clinical Research. Maryland: Lippincott Williams and Wilkins 4th edition, 2013
  2. Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. An Internet-Based Randomized, Placebo-Controlled Trial of Kava and Valerian for Anxiety and Insomnia. Medicine (Baltimore) 2005; 84:197-207. PMID: 16010204.
  3. Rowbotham MC, Astin J, Greene K, Cummings SR. Interactive informed consent: randomized comparison with paper consents. PLoS One. 2013;8(3):e58603. PMC3590180.

Multicenter studies

  1. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM. Risk factors for hip fracture in white women: The Study of Osteoporotic Fractures. N Engl J Med 1995; 332:767-73. PMID: 7862179
  2. Cummings SR, Black DM, Thompson DE, et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures. Results from the Fracture Intervention Trial. JAMA 1998; 280:2077-2082. PMID: 9875874
  3. Cummings SR, San Martin J, McClung MR, et al. FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009; 361: 756-65. PMID: 19671655

Epidemiology of osteoporosis and fractures

  1. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM for the Study of Osteoporotic Fractures Research Group. Bone density at various sites for prediction of hip fractures. Lancet 1993;341:72-5. PMID: 8093403
  2. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM. Risk factors for hip fracture in white women: The Study of Osteoporotic Fractures. N Engl J Med 1995; 332:767-73. PMID: 7862179
  3. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B and The Study of Osteoporotic Fractures Research Group. Endogenous hormones and the risk of hip and vertebral fractures among older women. N Engl J Med 1998; 339:733-8. PMID: 9731089.

Prevention of fractures: pivotal clinical trials

  1. Cummings SR, Black DM, Thompson DE, et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures. Results from the Fracture Intervention Trial. JAMA 1998; 280:2077-2082. PMID: 9875874
  2. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, et al. Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 1996; 348:1535-41. PMID: 8950879.
  3. Cummings SR, Ettinger B, Delmas PD, et al. The effects of tibolone in older postmenopausal women. Results of the Long-Term Intervention on Fractures with Tibolone (LIFT) Randomized Trial. New Engl J Med 2008 14;359:753-5. PMID: 18703472; PMC3684062.
  4. Cummings SR, San Martin J, McClung MR, et al. FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009; 361: 756-65. PMID: 19671655

Book

Hulley SB, Cummings SR, Browner WS, Grady Dg, Newman TB (eds). Designing Clinical Research. Maryland: Lippincott Williams and Wilkins, 4rd edition, 2013.